Bone density loss from Anastrozole partially reverses after treatment stops

A study by researchers from Queen Mary University of London shows that bone loss known to be associated with the use of the breast cancer prevention drug Anastrozole partially reverses, particularly at the lumbar spine, after stopping treatment.

Anastrozole is a hormone treatment recommended by NICE to prevent breast cancer in high-risk postmenopausal women.

The results, published in the British Journal of Cancer, are from a sub-study of 1,410 women from the International Breast cancer Intervention Study (IBIS-II) which investigated bone density in women who had completed anastrozole treatment.

At the seven year mark, two years after women stopped treatment, the study found that those with weakened bones experienced an increase in bone density at the lumbar spine. The increase did not occur at the total hip. The results suggest that decreased bone mineral density due to anastrozole treatment improves after anastrozole treatment is stopped.

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