Researchers find that patients with acne have reduced expression of the protein GATA6

An international team of researchers has found that patients with acne have lower levels of expression of the protein GATA6 in their skin. In their paper published in the journal Nature Communications, the group describes their study of skin biopsies taken from acne patients and what they found.

Acne is a skin condition that involves infected or inflamed sebaceous glands. It typically presents itself as facial pimples but can also be found on other parts of the body. Acne has been linked to excess sebum (oil) production, clogging of hair follicles, bacterial infections and general inflammation. It is also most prevalent during the teenage years. Acne is considered to be one of the most common skin diseases, affecting approximately 650 million people around the world. It can be treated with a variety of over-the-counter medicines, none of which are considered to be a cure-all. In this new effort, the researchers have found a connection between people whose skin produces less of the protein GATA6 and acne.

GATA6 is expressed in the upper part of the skin in hair follicles and other sebaceous glands. Prior research has shone it to be a zinc finger transcription factor and it plays a role in organ tissue differentiation.

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