Quality improvement program increases pneumococcal vaccination in adults with advanced kidney disease


In a study published in the American Journal of Kidney Diseases (AJKD), a quality improvement program that utilized electronic best practice alerts within the electronic medical record boosted pneumococcal vaccination rates from 53% to 70% (P < 0.001) in adults aged 18-64 years with stage 4 and 5 chronic kidney disease.

Pneumococcal vaccination (PV) rates are low in patients with chronic kidney disease (CKD) stages 4 and 5 and nephrotic syndrome, despite higher incidence of pneumococcal pneumonia and increased mortality and cardiovascular complications in these patients compared to patients without CKD. Researchers at the University of Pittsburgh implemented a quality improvement (QI) project involving a best practice alert (BPA) implementation in CKD clinics to improve PV rates amongst these high-risk patients over a 2-year period.

The intervention consisted of a BPA designed to electronically screen patients for PV eligibility based on diagnosis, age and vaccination status using a predetermined algorithm for eligibility criteria. The BPA appeared on the Electronic Medical Record (EMR) screen at the beginning of the patient encounter, as the medical assistant (MA) reviewed patient medications. The BPA allowed the MA to order the vaccine or document the reason for vaccine refusal or deferral. If the PV was deferred for any reason, then the BPA reappeared in 6 months. If the patient refused the vaccine, an alert was sent to the clinician to further educate the patient and the BPA was disabled for one year.

In the post-intervention group, 617 (53.8%) patients had been vaccinated prior and BPA appeared for 529 patients. There was a statistically significant increase in the percentage of patients who received at least one dose of the PV in the post-intervention group compared to the pre-intervention group (70.2% vs 62.7%, P = 0.0008) primarily due to increase in PV from 53% to 70% in patients between 18-64 years of age (P < 0.001). The vaccination rates in the groups aged 65 or older did not improve. BPA compliance, defined as either documentation of vaccine given/prescribed or the reason for refusal or deferral, was 45.9%.

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